Stability of Oral Oxytocics in Tropical Climates - Results of Simulation Studies on Oral Ergometrine, Oral Methylergometrine, Buccal Oxytocin and Buccal Desamino-Oxytocin - EDM Research Series No. 012
(1994; 52 pages) Voir le document au format PDF
Table des matières
Afficher le documentAbbreviations
Afficher le documentSummary
Ouvrir ce répertoire et afficher son contenuIntroduction
Ouvrir ce répertoire et afficher son contenuMaterials and methods
Fermer ce répertoireResults
Afficher le documentErgometrine (E)
Afficher le documentMethylergometrine (ME)
Afficher le documentOxytocin (OT)
Afficher le documentDesamino-oxytocin (DOT)
Ouvrir ce répertoire et afficher son contenuDiscussion
Afficher le documentConclusions and recommendations
Afficher le documentReferences
Ouvrir ce répertoire et afficher son contenuAnnexes
 

Methylergometrine (ME)

The level of active ingredient in the product declined under all conditions over time. After 21 weeks under refrigerated storage (D6/83), the level of active ingredient fell below 90%. After 21 weeks at D40/75, only 63.2% of the active ingredient remained, and only 50% after 52 weeks of exposure (Figure 1).

The influence of humidity on stability was stronger than the influence of temperature (Figure 2). After 21 weeks at D30/75 the product had 64.2% of the stated amount of the active ingredient left. At 52 weeks at D40/25, 51.6% of the active ingredient was left.

In all conditions the stability of uncoated E tablets was far less than that of the coated ME tablets. Instability increased under extreme humid conditions (D30/75 or D40/75), and hot conditions (D40/25), for both E and ME. From week 31 onwards the coating no longer seems to protect the compound for stability. This seems to be the case more or less independent of the exposure condition (Figures 1,2).

vers la section précédente
vers la section suivante
 
 
Le Portail d'information - Médicaments essentiels et produits de santé a été conçu et est maintenu par l'ONG Human Info. Dernière mise à jour: le 1 décembre 2019