Stability of Oral Oxytocics in Tropical Climates - Results of Simulation Studies on Oral Ergometrine, Oral Methylergometrine, Buccal Oxytocin and Buccal Desamino-Oxytocin - EDM Research Series No. 012
(1994; 52 pages) Voir le document au format PDF
Table des matières
Afficher le documentAbbreviations
Afficher le documentSummary
Ouvrir ce répertoire et afficher son contenuIntroduction
Ouvrir ce répertoire et afficher son contenuMaterials and methods
Fermer ce répertoireResults
Afficher le documentErgometrine (E)
Afficher le documentMethylergometrine (ME)
Afficher le documentOxytocin (OT)
Afficher le documentDesamino-oxytocin (DOT)
Ouvrir ce répertoire et afficher son contenuDiscussion
Afficher le documentConclusions and recommendations
Afficher le documentReferences
Ouvrir ce répertoire et afficher son contenuAnnexes
 

Ergometrine (E)

The level of active ingredient in the product decreased over time under all conditions. Under refrigerated storage (D6/83) the level of active ingredient remained above 90% for 3 weeks. After that it no longer met pharmaceutical requirements. At D40/75 ergometrine was very unstable, with only 26.5% of the active ingredient left after 3 weeks, and 1% after 52 weeks of exposure (Figure 1).

The influence of humidity on stability is stronger than the influence of temperature (Figure 2). After 21 weeks at 30°C in darkness and 75%RH (D30/75), the product had only 24% of the stated amount of the active ingredient. Exposed to D40/25 for 52 weeks, 44.9% of the stated amount of active ingredient remained. The influence of light seems less harmful than that of humidity (Figure 3).

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