(1994; 52 pages)
The level of active ingredient in the product decreased over time under all conditions. Under refrigerated storage (D6/83) the level of active ingredient remained above 90% for 3 weeks. After that it no longer met pharmaceutical requirements. At D40/75 ergometrine was very unstable, with only 26.5% of the active ingredient left after 3 weeks, and 1% after 52 weeks of exposure (Figure 1).
The influence of humidity on stability is stronger than the influence of temperature (Figure 2). After 21 weeks at 30°C in darkness and 75%RH (D30/75), the product had only 24% of the stated amount of the active ingredient. Exposed to D40/25 for 52 weeks, 44.9% of the stated amount of active ingredient remained. The influence of light seems less harmful than that of humidity (Figure 3).