WHO Supplementary Training Modules: Validation, Water, Air Handling Systems - Water for Pharmaceutical Use (Part 3): Inspection of Water Systems: Water for Pharmaceutical Use

WHO Supplementary Training Modules: Validation, Water, Air Handling Systems - Water for Pharmaceutical Use (Part 3): Inspection of Water Systems
(2006; 30 pages)

Table des matières

	Supplementary Training Modules on Good Manufacturing Practice
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for pharmaceutical use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use
	Water for Pharmaceutical Use

Water for Pharmaceutical Use

Other checks (7)

Activated carbon bed sanitization
Temperature-compensated conductivity meters
Influence of plastic pipe adhesive on TOC
Non-condensable gases in pure steam

Inspection: (Contd.)

Further points to check:

1. Activated carbon bed sanitization - these can become overgrown with bacteria quite quickly. Check sanitization frequency to ensure the AC remains uncontaminated.

2. Calibration of temperature-compensated conductivity meters is often overlooked or not done properly.

3. Influence of plastic pipe adhesive on Total Organic Carbon (TOC) compliance - some adhesives will leach into the water and these can be volatile.

4. Non-condensable gases in pure steam - for example nitrogen and oxygen. They affect the apparent pressure of sterilization processes, lowering their effectiveness.