Although there are now some effective single dose oral treatments, they are not known to be safe or effective. Only topical azoles should be used to treat pregnant women. Of those treatments that have been investigated for use during pregnancy, the most effective are miconazole, clotrimazole, butoconazole and terconazole.
It is recommended that predisposing factors such as antibiotic use, the use of antiseptic/antibiotic vaginal preparations or vaginal douching be reduced or eliminated. Simultaneous treatment of a rectal focus with oral nystatin or fluconazole is not useful in preventing recurrences. Other underlying factors for recurrent vulvovaginal candidiasis include uncontrolled diabetes mellitus, immunosuppression, and corticosteroid use.