WHO Model Prescribing Information: Drugs Used in Anaesthesia
(1989; 60 pages) [French] Voir le document au format PDF
Table des matières
Afficher le documentPreface
Afficher le documentIntroduction
Ouvrir ce répertoire et afficher son contenuPremedication
Ouvrir ce répertoire et afficher son contenuGeneral anaesthetics and oxygen
Ouvrir ce répertoire et afficher son contenuLocal anaesthetics
Ouvrir ce répertoire et afficher son contenuNon-opioid analgesics
Ouvrir ce répertoire et afficher son contenuOpioid analgesics and antagonists
Ouvrir ce répertoire et afficher son contenuMuscle relaxants and cholinesterase inhibitors
Ouvrir ce répertoire et afficher son contenuBlood substitutes
Fermer ce répertoireSolutions for correcting water and electrolyte imbalance
Afficher le documentCompound solution of sodium lactate
Afficher le documentGlucose
Afficher le documentGlucose with sodium chloride
Afficher le documentSodium chloride
Afficher le documentPotassium chloride
Ouvrir ce répertoire et afficher son contenuAntacid for use in obstetric practice
Afficher le documentAnaesthesia at the District Hospital
Afficher le documentSelected WHO publications of related interest
Afficher le documentBack cover
 

Sodium chloride

Group: intravenous infusion fluid
Injectable isotonic solution: 9 mg/ml (0.9%); Na+ 154 mmol/litre, Cl- 154 mmol/litre

General information

Sodium is the major extracellular cation. Maintenance of physiological concentrations is vital to effective regulation of the osmotic pressure of blood and tissues.

Clinical information

Uses

• Preoperative correction of fluid and sodium depletion.
• Replacement of extracellular fluid during surgery.
• Initial restoration of circulatory volume in hypovolaemic shock.

Dosage

Individual fluid requirements must be determined on the basis of clinical and, whenever possible, electrolyte monitoring. As a general guide in adults:

Preoperative fluid replacement: 50 ml/minute as an alternative to compound solution of sodium lactate.

Fluid replacement during surgery: 5 ml/minute as an alternative to compound solution of sodium lactate.

Acute hypovolaemic shock: as an alternative to compound solution of sodium lactate until vasoconstriction disappears and systolic blood pressure reaches 100 mmHg (13.3 kPa).

Precautions

Patients must be carefully monitored throughout the infusion for signs of intra-vascular overload, particularly when large volumes are administered rapidly. Should this occur, the infusion must be slowed or suspended and, if necessary, a rapidly acting diuretic administered (for example furosemide 40 mg i.v).

Adverse reactions

Unduly rapid replacement can lead to pulmonary oedema.

Overdosage

Excessive infusion may result in sodium retention. Symptoms of hypernatraemia include restlessness, weakness, thirst, dry swollen tongue, flushing of the skin, pyrexia and tachycardia.

Storage

Sodium chloride solution should be stored in sealed containers.

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