UK. The Summary of Product Characteristics (SPC) for atorvastatin (Lipitor) has been revised to include the interaction between atorvastatin and grapefruit juice. The SPC now states that grapefruit juice contains one or more components that inhibit CYP3A4 and can increase plasma concentrations of drugs metabolised by CYP3A4. Concomitant intake of large quantities of grapefruit juice and atorvastatin is therefore not recommended.

Reference:

SPC for Lipitor, http://emc.medicines.org.uk, 10 November 2004.