WHO Pharmaceuticals Newsletter 2003, No. 03
(2003; 14 pages) Ver el documento en el formato PDF
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Abrir esta carpeta y ver su contenidoREGULATORY MATTERS
Cerrar esta carpetaSAFETY OF MEDICINES
Ver el documentoANTIRETRO-VIRALS - Benefit/Risk balance remains strongly positive for combination antiretroviral therapy
Ver el documentoCYPROTERONE ACETATE & ETHINYL-ESTRADIOL - Update on risk of venous thromboembolism
Ver el documentoDIETHYL-STILBESTROL - Gynaecological and obstetric complications after in utero exposure
Ver el documentoEPHEDRA - Moves to reduce risks of ephedra-containing products
Ver el documentoFLUTICASONE PROPIONATE - Reports of adrenal crisis
Ver el documentoGRAPEFRUIT JUICE - Revised advice from ADRAC
Ver el documentoHORMONE REPLACEMENT THERAPY (HRT) - Risk of dementia
Ver el documentoOMEPRAZOLE, RABEPRAZOLE - Reports of interstitial nephritis
Ver el documentoROFECOXIB, CELECOXIB - Case reports support causal association with liver toxicity
Ver el documentoROSIGLITA-ZONE, PIOGLITAZONE - Adverse reactions update
Ver el documentoSOMATROPIN - Not to be authorized for AIDS-related wasting syndrome
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Abrir esta carpeta y ver su contenidoFEATURE
 

GRAPEFRUIT JUICE - Revised advice from ADRAC

Australia. The Adverse Drug Reactions Advisory Committee (ADRAC) in Australia has revised its previous advice (WHO Pharmaceuticals Newsletters No.3, 2002 and No.1, 2003) relating to grapefruit juice interactions. The committee notes that, although there have been no reports of significant clinical problems occurring when grapefruit juice and medication ingestion are separated by more than a few hours, grapefruit juice has the potential to have an interacting effect for up to 3 days after ingestion. ADRAC now considers that "the safest course is to avoid grapefruit and its juice altogether when taking medicines that interact". Statins and calcium channel blockers are some of the classes of drugs reported to interact with grapefruit juice.

Reference:

Australian Adverse Drug Reactions Bulletin 22: 8, Apr 2003.

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