abciximab
ReoPro, Eli Lilly: Malaysia
solution for injection 2 mg/ml
(vials 5 ml and 20 ml)
platelet aggregation inhibitor
Indications: Coronary angioplasty.
*basiliximab
Simulect, Novartis: Switzerland
solution for injection 20 mg/5ml vial
platelet aggregation inhibitor
Indications: Kidney transplant rejection.
*dexketoprofen
Sympal; Enantyum: Menarini: Germany
coated tablets 12.5, 25 mg
nonsteroidal anti-inflammatory agent
Indications: Symptomatic treatment of moderate to severe pain.
donepezil
Aricept, Pfizer: Iceland
coated tablets 5 mg, 10 mg
cholinesterase inhibitor
Indications: Symptomatic treatment of mild to moderate Alzheimer’s disease.
ferumoxides
Feridex, Ferumoxides: Eiken: Japan
intravenous injection 56 mg Fe/ampoule
diagnostic aid; contrast medium
Indications: Diagnosis of location of hepatic tumors in magnetic resonance imagining computed tomography.
fexofenadine
Telfast, Hoechst Merrell Dow: Spain
tablet 180 mg
histamine H1-antagonist (metabolite of terfenadine)
Indication: Relief of symptoms associated with seasonal allergic rhinitis in adults.
*incadronate disodium
Bisphonal, Yamanouchi: Japan
solution for intravenous infusion 10 mg/ampoule
biphosphonate
Indications: Hypercalcaemia due to malignant tumours.
Contraindications: Patients with a history of hypersensitivity to this product or other biphosphonates. Safety in pregnant women, infants and children has not been established.
Precautions: The usefulness of this product in the treatment of hypercalcaemia due to reasons other than malignant tumours (such as parathyroidal hyperactivity) has not been established. To be used with caution in patients with serious renal disorders, patients with cardiac disease, debilitated patients, and the elderly. Renal function tests should be performed after administration.
Adverse reactions: Fever, hypotension, disturbed consciousness; renal effects (raised levels of urinary protein, sugar, bilirubin, increased sediment); hepatic effects (raised serum transaminases and LDH); haematological effects (leukocytosis, neutrophilia, eosinopenia, lymphopenia).
irinotecan
Campto, Rhone-Poulenc Rorer: Switzerland
infusion concentrate 40 mg/2 ml vial;
100 mg/5 ml vial
antineoplastic agent
Indications: [Not stated].
lacidipine
Lacidipine BI Pharma, Boehringer-Ingelheim: Germany
tablet 2, 4 mg
calcium channel blocker
Indications: Essential hypertension.
metergoline
Liserdol, Kohl Pharma: Germany
coated tablet 4 mg
prolactin antagonist
Indications: Suppression of lactation; galactorrhoea, prolactin-dependent amenorrhoea; prolactin-dependent infertility in women; disturbances of fertility, diminished libido and impotence in men.
modafinil
Modiodal, Lab. L. Lafon: Germany
tablets 100 mg
psychostimulant
Indications: Narcolepsy with or without cataplexy.
nelfinavir
Viracept, Roche: Spain, UK
tablet 250 mg
HIV protease inhibitor; antiretroviral agent
Indications: Treatment of HIV-1 infected patients with advanced or progressive immunodeficiency, in combination with antiretroviral nucleoside analogues.
nevirapine
Viramune, Boehringer Ingelheim: EC, Spain, UK
tablet 200 mg
HIV-1 non-nucleoside reverse transcriptase inhibitor; antiretroviral agent
Indications: Patients with advanced or progressive HIV infection as part of combination therapy with nucleoside analogues.
*pentazocine + naloxone
Pentagin: Sankyo: Japan
tablet 25 mg + 250 micrograms
narcotic analgesic + morphine antagonist
Indications: Relief of pain in various types of cancer.
Contraindications: Patients who are hypersensitive to pentazocine or naloxone, patients with head injuries or intracranial hypertension, severe respiratory depression or severely impaired health. Precautions: Patients with a history of drug dependence, biliary tract disease, myocardial infarction, hepatic dysfunction and elderly patients. Patients shouldnot operate machinery or drive during treatment.
Adverse reactions: Shock, respiratory depression.
prasterone
Mylis, Kanebo: Japan
vaginal suppository 600 mg
hormone
Indications: Promotion of cervical ripening insufficiency in the third trimester of pregnancy.
quetiapine
Seroquel, Zeneca: Bahrain, Iceland
tablets 25 mg, 100 mg, 200 mg
neuroleptic benzodiazepine derivative with antipsychotic effect
Indications: Treatment of schizophrenia.
ritonavir
Norvir: Abbott: Japan
capsule 100 mg
antiretroviral agent
Indications: In combination with nucleoside analogue reverse transcriptase inhibitors for the treatment of AIDS and symptomatic and asymptomatic HIV infection with pre-treatment CD4 lymphocyte count of 500/mm3 or less.
*sildenafil
Viagra, Pfizer: EC, Switzerland
tablets 25 mg, 50 mg, 100 mg
cGMP-specific phosphodiesterase type 5
Indication: Erectile dysfunction.
Contraindications: Known history of hypersensitivity to any component of the product. Concurrent administration to patients using organic nitrates in any form.
Precautions: Patients should undergo a thorough cardiovascular examination before starting treatment. Adverse reactions: Headache, flushing, abnormal vision.
Note: First approved in the USA - see Pharmaceuticals Newsletter Nos. 5&6, May & June 1998.
*stavudine
Zerit, Bristol-Myers Squibb: Japan
capsules 15 mg, 20 mg
antiretroviral agent
Indications: AIDS; symptomatic or asymptomatic treatment of HIV infection with CD4 count of 500/mm3 or less before treatment. Note: Not to be used as monotherapy as a first-line therapy.
tetracycline and metronidazole and bismuth subcitrate
Panmycin, Trichozole, De-Nol: Pharmacia & Upjohn: New Zealand
tetracycline: capsule 250 mg
metronidazole: tablet 400 mg
bismuth subcitrate: 120 mg
(triple therapy pack)
antibiotic + antiprotozoal agent + bismuth salt
Indications: Triple therapy for the eradication of Helicobacter pylori (tetracycline four times a day, metronidazole three times a day and bismuth subcitrate four times a day, for 14 days).
tropisetron
Navoban, Novartis: Japan
capsule 5 mg
serotonin receptor antagonist; antiemetic
Indications: Cancer-chemotherapy induced gastrointestinal symptoms including nausea and vomiting (e.g. cisplatin).
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