Stated amount: 95µg free base methylergometrine (= 100%) test I: D6/83
time (weeks) |
mean conc/tablet (HPLC) |
% HPLC |
SD |
SD/mean x100% CV% |
n |
0 |
0.089 |
93.7 |
0.008 |
9.0 |
20 |
3 |
0.093 |
97.9 |
0.009 |
9.7 |
4 |
7 |
0.093 |
97.9 |
0.003 |
3.2 |
4 |
14 |
0.090 |
94.7 |
0.001 |
1.1 |
4 |
21 |
0.088 |
92.6 |
0.003 |
3.4 |
4 |
30 |
0.050 |
52.6 |
0.002 |
4.0 |
4 |
40 |
0.055 |
57.9 |
0.004 |
7.3 |
4 |
52 |
0.056 |
58.9 |
0.003 |
5.4 |
11 |
test II: D20/75
time (weeks) |
mean conc/tablet (HPLC) |
% HPLC |
SD |
SD/mean x100% CV% |
n |
0 |
0.089 |
93.7 |
0.003 |
9.0 |
20 |
3 |
0.100 |
115.8 |
0.006 |
6.0 |
4 |
7 |
0.083 |
87.4 |
0.004 |
4.8 |
4 |
14 |
0.078 |
82.1 |
0.003 |
3.8 |
4 |
21 |
0.056 |
58.9 |
0.003 |
5.4 |
4 |
30 |
0.049 |
51.6 |
0.002 |
4.1 |
4 |
40 |
0.053 |
55.8 |
0.001 |
1.9 |
4 |
52 |
0.054 |
56.8 |
0.004 |
7.4 |
12 |
test III: D30/45
time (weeks) |
mean conc/tablet (HPLC) |
% HPLC |
SD |
SD/mean x100% CV% |
n |
0 |
0.089 |
93.7 |
0.008 |
9.0 |
20 |
3 |
0.089 |
93.7 |
0.007 |
7.9 |
4 |
7 |
0.072 |
85.2 |
0.013 |
18.1 |
4 |
14 |
0.059 |
62.1 |
0.001 |
1.7 |
4 |
21 |
0.042 |
44.2 |
0.002 |
4.8 |
4 |
30 |
0.046 |
48.4 |
0.001 |
2.2 |
4 |
40 |
0.056 |
58.9 |
0.001 |
1.8 |
4 |
52 |
0.050 |
52.6 |
0.003 |
6.0 |
12 |
Methylergometrine 0.125 mg tablets
test IV: D30/75
time (weeks) |
mean conc/tablet (HPLC) |
% HPLC |
SD |
SD/mean x100% CV% |
n |
0 |
0.089 |
93.7 |
0.008 |
9.0 |
20 |
3 |
0.079 |
83.2 |
0.009 |
11.4 |
4 |
7 |
0.075 |
78.9 |
0.005 |
6.7 |
4 |
14 |
0.077 |
81.1 |
0.001 |
1.3 |
4 |
21 |
0.061 |
64.2 |
0.001 |
1.6 |
4 |
30 |
0.047 |
49.5 |
0.000 |
0 |
4 |
40 |
0.053 |
55.8 |
0.001 |
1.9 |
4 |
52 |
0.047 |
49.5 |
0.003 |
6.4 |
12 |
test V: D40/25
time (weeks) |
mean conc/tablet HPLC |
% HPLC |
SD |
SD/mean x100% CV% |
n |
0 |
0.089 |
93.7 |
0.008 |
9.0 |
20 |
3 |
0.093 |
97.9 |
0.008 |
8.6 |
4 |
7 |
0.090 |
94.7 |
0.004 |
4.4 |
4 |
14 |
0.091 |
95.8 |
0.001 |
1.1 |
4 |
21 |
0.076 |
80.0 |
0.004 |
5.3 |
4 |
30 |
0.046 |
48.4 |
0.002 |
4.3 |
4 |
40 |
0.052 |
54.7 |
0.000 |
0 |
4 |
52 |
0.049 |
51.6 |
0.002 |
4.1 |
12 |
test VI: D40/75
time (weeks) |
mean conc/tablet (HPLC) |
% HPLC |
SD |
SD/GEM x100% CV% |
n |
0 |
0.089 |
93.7 |
0.008 |
9.0 |
20 |
3 |
0.084 |
88.4 |
0.013 |
15.5 |
4 |
7 |
0.083 |
87.4 |
0.004 |
4.8 |
4 |
14 |
0.083 |
87.4 |
0.004 |
4.8 |
4 |
21 |
0.060 |
63.2 |
0.003 |
5.0 |
4 |
30 |
0.044 |
46.3 |
0.003 |
6.8 |
4 |
40 |
0.046 |
48.0 |
0.002 |
4.3 |
4 |
52 |
0.040 |
42.1 |
0.002 |
5.0 |
12 |
Methylergometrine 0.125 mg tablets test VII: L20/30
time (weeks) |
mean conc/tablet HPLC |
% HPLC |
SD |
SD/mean x100% CV% |
n |
0 |
0.089 |
93.7 |
0.008 |
9.0 |
20 |
3 |
0.097 |
102.1 |
0.003 |
3.1 |
4 |
7 |
0.072 |
75.8 |
0.006 |
8.3 |
4 |
14 |
0.081 |
85.3 |
0.001 |
1.2 |
4 |
21 |
0.061 |
64.2 |
0.003 |
4.9 |
4 |
30 |
0.048 |
50.5 |
0.001 |
2.1 |
4 |
40 |
0.054 |
56.8 |
0.002 |
3.7 |
4 |
52 |
0.054 |
56.8 |
0.002 |
3.7 |
12 |
Methylergometrine 0.125 mg tablets
test III: D30/45; packed in aluminium foil
time (weeks) |
mean conc/tablet (HPLC) |
% HPLC |
SD |
SD/mean x100% CV% |
n |
12 |
0.042 |
44.2 |
|
|
7 |
41 |
0.062 |
65.3 |
|
|
12 |
test IV: D30/75; packed in aluminium foil
time (weeks) |
mean conc/tablet (HPLC) |
% HPLC |
SD |
SD/GEM x100% CV% |
n |
12 |
0.049 |
51.6 |
|
|
8 |
41 |
0.060 |
63.2 |
|
|
12 |
test V: D40/25; packed in aluminium foil
time (weeks) |
mean conc/tablet (HPLC) |
% HPLC |
SD |
SD/mean x100% CV% |
n |
20 |
0.049 |
51.6 |
|
|
4 |
test VI: D40/75; packed in aluminium foil
tijd (wkn) |
gem. HPLC abs |
% HPLC |
SD |
SD/GEM x100% |
n |
12 |
0.047 |
49.5 |
|
|
8 |
20 |
0.044 |
46.3 |
|
|
6 |
test VII: L20/30; packed in aluminium foil
time (weeks) |
mean conc/tablet (HPLC) |
% HPLC |
SD |
SD/mean x100% CV% |
n |
12 |
0.051 |
53.7 |
|
|
8 |
41 |
0.052 |
54.7 |
|
|
6 |
test VII: L20/30; packed in sealed poly-ethylene
time (weeks) |
mean conc/tablet (HPLC) |
% HPLC |
SD |
SD/mean x100% CV% |
n |
41 |
0.057 |
60.0 |
|
|
24 |
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