Stability of Oral Oxytocics in Tropical Climates - Results of Simulation Studies on Oral Ergometrine, Oral Methylergometrine, Buccal Oxytocin and Buccal Desamino-Oxytocin - EDM Research Series No. 012: Materials and methods: Simulated tropical conditions

Stability of Oral Oxytocics in Tropical Climates - Results of Simulation Studies on Oral Ergometrine, Oral Methylergometrine, Buccal Oxytocin and Buccal Desamino-Oxytocin - EDM Research Series No. 012
(1994; 52 pages)

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Simulated tropical conditions

The design of this study followed the recommendations laid down in the "Protocol for research on the stability of drugs in aqueous solutions" by the Dutch Society of Hospital Pharmacists (19). Tropical conditions were simulated (Table II). Taking into account the known vulnerability of ergometrine and methylergometrine to exposure to light, all tablets were tested for light specific degradation (18).

Table II: Definitions of simulated tropical conditions

Test	Storage condition			Notation of conditions in text and figures
		Temperature	Relative humidity
I	dark (D)	6-10°C	ambient: 83-85%	D6/83
II	dark (D)	20°C	75%	D20/75
III	dark (D)	30°C	45%	D30/45
IV	dark (D)	30°C	75%	D30/75
V	dark (D)	40°C	ambient: 12-28%	D40/25
VI	dark (D)	40°C	75%	D40/75
VII	light (L)	20-25°C; room temperature	ambient: 20-35%	L20/30