Group: antifungal agent
Tablet, 500 000 IU[EDL]
Pessary, 100 000 IU [EDL]

General information

Nystatin is an antifungal polyene antibiotic derived from Streptomyces noursei. It is effective against infections caused by a wide range of yeasts and yeast-like fungi.

Clinical information

Uses

Treatment of oral and vaginal candidiasis.

Dosage and administration

Vaginal candidiasis:

100 000 - 1 000 000 IU as pessaries inserted high into the vagina nightly for at least 2 weeks.

Administration should be continued for 48 hours after clinical cure. Higher doses and longer period of treatment may be necessary in immunocompromised patients.

Oral candidiasis:

One tablet four times daily; tablets should be sucked, not swallowed, and retained in the mouth for as long as possible. Therapy should be continued for at least 48 hours after symptoms have resolved.

Contraindications and precautions

Treatment should be discontinued if symptoms of irritation or sensitization occur.

Use in pregnancy

Nystatin is poorly absorbed, if at all. It has been shown to be safe in pregnancy.

Adverse effects

Mild and transient nausea, vomiting and diarrhoea may occur after oral administration. Irritation rarely occurs after topical application.

Storage

Tablets should be stored in well-closed containers. Pessaries should be stored below 15°C in well-closed containers, protected from light.