From Access to Adherence: The Challenges of Antiretroviral Treatment - Studies from Botswana, Tanzania and Uganda, 2006
(2006; 320 pages) Ver el documento en el formato PDF
Índice de contenido
Ver el documentoAcknowledgments
Ver el documentoAcronyms and abbreviations
Ver el documentoForeword
Abrir esta carpeta y ver su contenido1. On hunger, transport costs and waiting time: a synthesis of challenges to ARV adherence in three African countries
Abrir esta carpeta y ver su contenido2. Overview of antiretroviral therapy, adherence and drug-resistance
Abrir esta carpeta y ver su contenido3. From training to action: the process of engaging health professionals in operational research on adherence to antiretroviral therapy
Ver el documento4. There's hope - early observations of ARV treatment roll-out in South Africa
Cerrar esta carpetaFactors that facilitate or constrain adherence to antiretroviral therapy among adults at four public health facilities in Botswana: a pre-intervention study
Ver el documentoAcknowledgements
Ver el documentoAcronyms and abbreviations
Ver el documentoExecutive summary
Abrir esta carpeta y ver su contenidoChapter 1: Introduction
Abrir esta carpeta y ver su contenidoChapter 2: Background
Abrir esta carpeta y ver su contenidoChapter 3: Methodology
Cerrar esta carpetaChapter 4: Quantitative results
Ver el documento4.1 Adherence measurement tool results
Ver el documento4.2 Rates of adherence to ARVs
Ver el documento4.3 Reasons for skipping medication
Ver el documento4.4 Factors affecting adherence to ART
Ver el documento4.5 Predictors of adherence to ART
Ver el documento4.6 Quantitative results of exit interviews
Abrir esta carpeta y ver su contenidoChapter 5: Qualitative results
Abrir esta carpeta y ver su contenidoChapter 6: Discussion, conclusion and recommendations
Ver el documentoReferences
Ver el documentoAnnex 1: Mean of rates adherence
Ver el documentoAnnex 2: Multivariate logistic regression analyses on the predictor variables
Ver el documentoAnnex 3: Questionnaires
Abrir esta carpeta y ver su contenidoA study on antiretroviral adherence in Tanzania: a pre-intervention perspective, 2005
Abrir esta carpeta y ver su contenidoFactors that facilitate or constrain adherence to antiretroviral therapy among adults in Uganda: a pre-intervention study
Ver el documentoBack cover
 

4.4 Factors affecting adherence to ART

4.4.1 Costs

Consistent with the current policy on registration costs, most participants either reported paying 2 pula/P2 (about 40 US cents) or did not pay anything. The P2 charge is the normal administrative fee payable by anyone who visits a health facility. Twenty-nine per cent of the participants indicated that they had experienced a loss of income as a result of coming to the clinic and 57% indicated changes in general expenditures. However, there was no significant association between employment status and reported loss of income (χ2=1.526; p=0.217). The median cost of travelling to the facility was P10 (approx US$ 2.00) and 80% of the participants reported spending less than P15 (approx US$ 2.50) for transport. The mean cost of transport was not significantly different between the optimally adherent and sub-optimally adherent (t=0.0208; P=0.978).

4.4.2 Gender and employment

Using the visual analogue method, no association was observed between gender and adherence (χ2=0.743; P=0.389). However, there is a significant association between employment status and adherence (χ2=5.116; P=0.024), suggesting that people who are employed are more likely to adhere to treatment. A higher proportion of the employed (65%) had optimal levels of adherence compared to 55% among the unemployed.


Figure 4.2: Adherence rates (measured by visual analogue) by sex and occupation

4.4.3 Knowledge of HIV and ARVs

The knowledge about HIV and ARVs was rated using eight questions worth one point each. Fifty-eight per cent of the participants got a score of at least 75%. For the purpose of evaluating the impact of knowledge on adherence, a cut-off of 75% was used (>75% good knowledge). A significant correlation was observed between knowledge of HIV and ARVs and adherence level (optimal and sub-optimal) for pill count (χ2=13.558; P<0.0001) and visual analogue (χ2=3.890; 0.049). However, there was no correlation between knowledge of HIV and ARVs and adherence levels in the two-day recall measure (χ2=1.127; P=0.288).

Table 4.4: Association between knowledge of HIV and ARVs with level of adherence and measures used

Measure

Level of Adherence

Good

Poor

χ2 value

P-value

Pill count*
(N = 322)

Sub-optimal

69

11

13.558

<0.0001

 

Optimal

156

86

   

Two-day recall
(N=496)

Sub-optimal

9

13

1.127

0.288

 

Optimal

255

231

   

Visual analogue
(N = 508)

Sub-optimal

95

106

3.890

0.049

 

Optimal

166

129

   

 

* Serowe data excluded from the analysis.


4.4.4 Education

There was no association between educational levels and adherence rates (χ2 =3.44; p=0.751).

4.4.5 Quality of health care services

The majority of the participants (92%) were satisfied with the quality of health care services.

4.4.6 Side-effects

Of the 58% of participants who reported having experienced side-effects, 8% reported having skipped their medication as a result.

4.4.7 Treatment supporters/reminders and appointments

Most of the participants (74%) said they had someone to remind them to take their medication. Twenty per cent reported having missed some appointments.

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Última actualización: le 3 mayo 2013