Cream, 5%

General information

Permethrin is a topical scabicidal agent for the treatment of infestations with Sarcoptes scabiei, Pediculus humanus capitis and P. humanus corporis. It acts on the nerve cell membranes of the parasites with consequent paralysis. It is more expensive than lindane and benzyl benzoate.

Absorption of permethrin is negligible following topical application.

Clinical information

Uses

Treatment of scabies and pediculosis of the scalp and body.

Dosage and administration

All doses are suitable for adults and children.

Scabies and Pediculus humanus corporis:

The cream should be massaged thoroughly into all skin surfaces, from the scalp to the soles of the feet, and left for at least 8 hours before rinsing. In general, 30 g is sufficient for an average adult. A single application is usually curative.

Pediculus humanus capitis:

The cream should be massaged into damp hair and left for 10 minutes before rinsing.

Household contacts should be treated at the same time. All combs and brushes should be soaked in a pediculicidal solution (see Parasitic infections - Prevention and management) for at least 2 hours.

Contraindication

Known hypersensitivity to synthetic pyrethroids or pyrethrins.

Use in pregnancy

Safe use in pregnancy has not been demonstrated. However, since absorption is negligible, it may be used if necessary.

Precautions

Pruritus, oedema and erythema may be exacerbated.

Adverse effects

Mild and transient burning and stinging sensations may occur after treatment, particularly in cases with severe infestation.

Storage

Cream should be stored in well-closed containers, below 25 °C.