Cream or lotion, 2.5%, 5%, 10%

General information

Benzoyl peroxide is a bacteriostatic agent that is used primarily in acne because of its activity against Propionibacterium acnes.

It is absorbed by the skin after topical application and metabolized to benzoic acid.

Clinical information

Uses

Treatment of mild to moderate acne vulgaris and as an adjunct to therapy in more severe cases.

Dosage and administration

Adults and adolescents: a thin layer of 2.5% or 5% cream or lotion should be applied to clean skin initially once daily on alternate days. The frequency of application is then gradually increased up to twice daily as tolerance develops. Unresponsive cases may require treatment with the 10% preparation.

Contraindications

Known hypersensitivity to benzoyl peroxide.

Precautions

Benzoyl peroxide should not be applied to open sores or broken skin. Contact with the eyes and mucous membranes should be avoided.

Use in pregnancy

Topically applied benzoyl peroxide is not systemically absorbed and can be used safely during pregnancy.

Adverse effects

Skin irritation is common after topical application but subsides with continued treatment.

Rarely, contact sensitivity has been reported.

Storage

Preparations should be stored in well-closed containers. They should not be allowed to freeze.