Tablet, 125 mg Cream, 1%

General information

Terbinafine is an allylamine. It has a narrow spectrum of antifungal activity after oral administration but is effective against the common superficial pathogens when applied topically. It is well absorbed following topical application and penetrates the epidermis in high concentrations. It is largely metabolized in the liver.

Clinical information

Uses

Treatment of ringworm (tinea), candidosis and onychomycosis.

Dosage and administration

All doses are suitable for adults and children.

Ringworm (tinea) and candidosis:

A thin layer of cream should be applied once or twice daily for 1-2 weeks. Symptoms usually resolve rapidly (within 3-7 days in tinea pedis).

Resistant tinea corporis or tinea pedis:

250 mg orally daily for 1-2 weeks.

Onychomycosis:

250 mg orally daily for 6-12 weeks.

Contraindications

Severe hepatic impairment.

Precautions

Liver function should be assessed before and at regular intervals during treatment in patients with mild hepatic impairment or alcohol dependence.

Use in pregnancy

Safe use in pregnancy has not been established. The need for treatment must be determined by the condition of the mother.

Adverse effects

Nausea and headache are common. Transient loss of taste may occur after oral administration. Hepatic toxicity is very rare.

Storage

Tablets and cream should be stored in well-closed containers, protected from light.