The WHO regularly publishes guidelines to direct the efforts of pediatric HIV treatment programs. Many national governments adapt these guidelines and use them to update their existing policies. This document assists implementers by providing a logical and comprehensive methodology to identify key issues in designing their individualized implementation plans for the new WHO pediatric treatment recommendations. It divides these issues into two broad categories: those that create an environment that enables the recommendations to be effectively implemented and those that address operational issues involved in implementing the recommendations; and provides technical direction and tools and resources for implementation.