This research protocol for the Karolinska-Harvard-WHO project on the comparative analysis of National Drug Policies (NDPs) in developing countries includes: brief description of the problem, the research question, and the study's objectives; the anticipated outcomes from the cross-national comparative study; a description of the principal analytic methods to be used; and the proposed work plan and project collaborators. The accompanying background paper (Govindaraj, 1994) presents a comprehensive review of the literature on the formulation, implementation, and evaluation of social programs; and provides the rationale and theoretical basis for the research protocol.