(1994; 115 pages) [French] [Spanish]
Steady state drug treatment
In steady state drug treatment two aspects are important. First, the mean plasma concentration is determined by the dose per day. The relation between dose and plasma concentration is linear: at double dose the mean plasma concentration also doubles.
Second, fluctuations in the curve are determined by the frequency of administration. With the same total dose per day, a higher frequency of administration gives fewer fluctuations in the curve (Figure 17). With a continuous infusion there are no fluctuations at all.
Figure 17: Dose dependent fluctuations in the Cp/time curve
If you decide to raise the dose it will again take about 4 half-lives before you reach the new steady state. The same applies when you decrease it by giving a lower dose.