Guide to Good Prescribing - A Practical Manual
(1994; 115 pages) [French] [Spanish] View the PDF document
Table of Contents
View the documentAcknowledgments
View the documentWhy you need this book
Open this folder and view contentsPart 1: Overview
Open this folder and view contentsPart 2: Selecting your P(ersonal) drugs
Open this folder and view contentsPart 3: Treating your patients
Open this folder and view contentsPart 4: Keeping up-to-date
Close this folderAnnexes
Close this folderAnnex 1: Essentials of pharmacology in daily practice
View the documentIntroduction
Open this folder and view contentsPharmacodynamics
Open this folder and view contentsPharmacokinetics
Close this folderDrug treatment
View the documentStarting drug treatment
View the documentSteady state drug treatment
View the documentStopping drug treatment
Open this folder and view contentsSpecial features of the curve
View the documentAnnex 2: Essential references
Open this folder and view contentsAnnex 3: How to explain the use of some dosage forms
Open this folder and view contentsAnnex 4. The use of injections
View the documentBack Cover
 
Steady state drug treatment

In steady state drug treatment two aspects are important. First, the mean plasma concentration is determined by the dose per day. The relation between dose and plasma concentration is linear: at double dose the mean plasma concentration also doubles.

Second, fluctuations in the curve are determined by the frequency of administration. With the same total dose per day, a higher frequency of administration gives fewer fluctuations in the curve (Figure 17). With a continuous infusion there are no fluctuations at all.


Figure 17: Dose dependent fluctuations in the Cp/time curve

If you decide to raise the dose it will again take about 4 half-lives before you reach the new steady state. The same applies when you decrease it by giving a lower dose.

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