Guide to Good Prescribing - A Practical Manual
(1994; 115 pages) [French] [Spanish] View the PDF document
Table of Contents
View the documentAcknowledgments
View the documentWhy you need this book
Open this folder and view contentsPart 1: Overview
Open this folder and view contentsPart 2: Selecting your P(ersonal) drugs
Open this folder and view contentsPart 3: Treating your patients
Open this folder and view contentsPart 4: Keeping up-to-date
Close this folderAnnexes
Close this folderAnnex 1: Essentials of pharmacology in daily practice
View the documentIntroduction
Open this folder and view contentsPharmacodynamics
Open this folder and view contentsPharmacokinetics
Close this folderDrug treatment
View the documentStarting drug treatment
View the documentSteady state drug treatment
View the documentStopping drug treatment
Open this folder and view contentsSpecial features of the curve
View the documentAnnex 2: Essential references
Open this folder and view contentsAnnex 3: How to explain the use of some dosage forms
Open this folder and view contentsAnnex 4. The use of injections
View the documentBack Cover
 
Starting drug treatment

The most important issue in starting treatment is the speed at which the curve reaches steady state, within the therapeutic window. If you give a fixed dose per unit of time, this speed is only determined by the half-life of the drug. On a fixed dosage schedule, steady state is reached after about 4 half-lives (Figure 16). In case of a long half-life it may therefore take some time for the drug to reach a therapeutic concentration. If you want to reach the window quicker, you can use a loading dose (see below).


Figure 16: Steady state is reached after 4 half-lives

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