Japan. Doctors in Japan have reported 831 serious adverse effects associated with methotrexate (Rheumatrex) to Wyeth K.K., between March 1999 and November 2004; 134 reports were of fatal adverse effects, including interstitial pneumonia and myelosuppression. An estimated 100 000 people are taking methotrexate (Rheumatrex) in Japan.

Wyeth K.K. has warned doctors and patients that methotrexate (Rheumatrex) is associated with 'life-threatening' and 'sometimes serious' adverse effects, and has requested that the drug be used carefully. However, pharmaceutical experts have demanded that the manufacturer and the government clearly outline the risks associated with methotrexate.

Reference:

Japanese Media Release, 12 February 2005. Available on the internet at www.japantimes.co.jp