FDCs will lead to simplified treatment regimens. A patient will be able to get one product instead of three or more different products. The number of tablets to be taken will be reduced (e.g. to as few as two tablets in a day for ARVs). Reducing pill burden has been shown to enhance adherence to treatment⁶.

FDCs will also reduce the chances of patients under-dosing because they cannot afford all the individual drugs at the same time or because one of the drugs from the combination is unavailable. This is usually a major problem when the patients have to pay for their drugs.