(1993; 36 pages)
9. Simple test methodology
Basic tests for verifying the identity of pharmaceutical substances and their associated dosage forms have now been published (6, 7) or are in the course of development for the majority of the substances in the current WHO Model List of Essential Drugs (1). The Committee recommended that the reagents specified for use in such tests should be chosen with care with respect to both their availability and their toxicity. In response to earlier suggestions (4) that complementary tests should be developed to detect gross degradation, a thin-layer chromatographic (TLC) procedure was in the course of evaluation. The Committee agreed that, providing such a procedure was shown to be sufficiently reliable, it could be recommended for use as a basic test.