WHO Model Prescribing Information: Drugs used in Bacterial Infections
(2001; 179 pages) View the PDF document
Table of Contents
View the documentPreface
View the documentIntroduction
Open this folder and view contentsUpper respiratory tract infections
Open this folder and view contentsLower respiratory tract infections
Open this folder and view contentsOther respiratory tract infections
Open this folder and view contentsPerioral and dental infections
Open this folder and view contentsGastrointestinal tract infections
Open this folder and view contentsUrinary tract infections
Open this folder and view contentsSkin and soft tissue infections
Open this folder and view contentsBone and joint infections
Open this folder and view contentsSexually transmitted diseases
Open this folder and view contentsCardiovascular infections
Open this folder and view contentsCentral nervous system infections
Open this folder and view contentsMiscellaneous infections
Open this folder and view contentsSepticaemia
Close this folderDrugs (for details of contraindications, etc., see individual drug entries)
View the documentAmoxicillin
View the documentAmoxicillin + clavulanic acid
View the documentAmpicillin
View the documentBenzylpenicillin
View the documentBenzathine benzylpenicillin
View the documentProcaine benzylpenicillin
View the documentCefalexin
View the documentCefazolin
View the documentCefotaxime
View the documentCeftazidime
View the documentCeftriaxone
View the documentCefuroxime
View the documentChloramphenicol
View the documentCiprofloxacin
View the documentClindamycin
View the documentCloxacillin1
View the documentDoxycycline
View the documentErythromycin
View the documentGentamicin
View the documentImipenem + cilastatin
View the documentMetronidazole
View the documentNalidixic acid
View the documentNitrofurantoin
View the documentNystatin
View the documentPhenoxymethylpenicillin
View the documentRifampicin
View the documentSpectinomycin
View the documentStreptomycin
View the documentSulfadiazine
View the documentSulfamethoxazole + trimethoprim
View the documentTetracycline
View the documentTinidazole
View the documentTrimethoprim
View the documentVancomycin
 

Phenoxymethylpenicillin

Tablet, 250 mg (as potassium salt)
Powder for oral suspension, 250 mg (as potassium salt)/5ml

General information

Phenoxymethylpenicillin is a semisynthetic derivative of penicillin for oral use. It is active against most Gram-positive bacteria but β-lactamase-producing strains (mainly staphylococci) are resistant.

It is well absorbed from the gastrointestinal tract and distributed widely in tissues. It is eliminated in the urine. It crosses the placenta and is eliminated in breast milk.

Clinical information

Uses

• Treatment of acute pharyngitis, acute cervical adenitis, gingival infections, periodontitis, tooth abscesses and suppurative odontogenic infections.

• Prevention of recurrence of rheumatic fever due to group A β-haemolytic streptococci in adults and children > 2 years.

• Postsplenectomy prophylaxis in adults and children > 2 years.


Dosage and administration

Acute pharyngitis and acute cervical adenitis

Adults: 500 mg orally every 6 hours for 10 days.

Children: 10 - 20mg/kg (maximum 500 mg) orally every 6 hours for 10 days.

Gingival infections and periodontitis

Adults: 500 mg orally every 6 hours for 5 days.

Children: 10 - 20mg/kg (maximum 500 mg) orally every 6 hours for 5 days.

Tooth abscesses and suppurative odontogenic infections

Adults: 500 mg orally every 6 hours for 3 days.

Children: 10 - 20mg/kg (maximum 500 mg) orally every 6 hours for 3 days.

Prevention of recurrence of rheumatic fever due to group A β-haemolytic streptococci and postsplenectomy prophylaxis in adults and children >2 years

Adults: 250 mg orally every 12 hours.

Children >2 years: 125 mg orally every 12 hours.

Contraindications

Known hypersensitivity to penicillins or cefalosporins.

Precautions

Facilities should be available for treating anaphylaxis whenever penicillins are used. Patients should be questioned carefully about previous allergic reactions before the first dose is administered. If a skin rash develops, the patient should be transferred to a different class of antimicrobial.

Use in pregnancy

There is no evidence that phenoxymethylpenicillin is teratogenic. It may be used during pregnancy.

Adverse reactions

Hypersensitivity reactions are most common, ranging in severity from skin rashes to immediate anaphylaxis. Mild diarrhoea can also occur.

Storage

Preparations should be stored in wellclosed containers.

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