(2001; 179 pages)
Nitrofurantoin is a nitrofuran-type antimicrobial with bacteriostatic activity against Escherichia coli and certain other Gram-negative bacteria.
Nitrofurantoin is readily absorbed from the gastrointestinal tract. Between 20 and 60% of the dose is bound to plasma proteins. It is partially metabolized in the liver and excreted in the urine. Therapeutic concentrations are reached within 30 minutes of dosing.
Treatment of urinary tract infections in adults.
Prophylaxis against urinary tract infections in children.
Dosage and administration
Urinary tract infections in adults
Women: 100 mg orally every 12 hours for 3 days (for uncomplicated infections).
Men: 100mg orally every 12 hours for at least 14 days.
Prophylaxis against urinary tract infections in children
50 mg orally at night.
Patients with impaired renal function.
Nitrofurantoin is generally well tolerated at the doses used. The most frequently reported adverse effect is nausea. If doses of 100 mg every 6 hours are used, gastrointestinal symptoms may be more severe.
Peripheral neuritis, pulmonary reactions, hepatotoxicity and haematological changes have been reported.
Tablets should be stored in well-closed containers.