WHO Model Prescribing Information: Drugs used in Bacterial Infections
(2001; 179 pages) View the PDF document
Table of Contents
View the documentPreface
View the documentIntroduction
Open this folder and view contentsUpper respiratory tract infections
Open this folder and view contentsLower respiratory tract infections
Open this folder and view contentsOther respiratory tract infections
Open this folder and view contentsPerioral and dental infections
Open this folder and view contentsGastrointestinal tract infections
Open this folder and view contentsUrinary tract infections
Open this folder and view contentsSkin and soft tissue infections
Open this folder and view contentsBone and joint infections
Open this folder and view contentsSexually transmitted diseases
Open this folder and view contentsCardiovascular infections
Open this folder and view contentsCentral nervous system infections
Open this folder and view contentsMiscellaneous infections
Open this folder and view contentsSepticaemia
Close this folderDrugs (for details of contraindications, etc., see individual drug entries)
View the documentAmoxicillin
View the documentAmoxicillin + clavulanic acid
View the documentAmpicillin
View the documentBenzylpenicillin
View the documentBenzathine benzylpenicillin
View the documentProcaine benzylpenicillin
View the documentCefalexin
View the documentCefazolin
View the documentCefotaxime
View the documentCeftazidime
View the documentCeftriaxone
View the documentCefuroxime
View the documentChloramphenicol
View the documentCiprofloxacin
View the documentClindamycin
View the documentCloxacillin1
View the documentDoxycycline
View the documentErythromycin
View the documentGentamicin
View the documentImipenem + cilastatin
View the documentMetronidazole
View the documentNalidixic acid
View the documentNitrofurantoin
View the documentNystatin
View the documentPhenoxymethylpenicillin
View the documentRifampicin
View the documentSpectinomycin
View the documentStreptomycin
View the documentSulfadiazine
View the documentSulfamethoxazole + trimethoprim
View the documentTetracycline
View the documentTinidazole
View the documentTrimethoprim
View the documentVancomycin
 

Nitrofurantoin

Tablet, 100mg

General information

Nitrofurantoin is a nitrofuran-type antimicrobial with bacteriostatic activity against Escherichia coli and certain other Gram-negative bacteria.

Nitrofurantoin is readily absorbed from the gastrointestinal tract. Between 20 and 60% of the dose is bound to plasma proteins. It is partially metabolized in the liver and excreted in the urine. Therapeutic concentrations are reached within 30 minutes of dosing.

Clinical information

Uses

Treatment of urinary tract infections in adults.

Prophylaxis against urinary tract infections in children.

Dosage and administration

Urinary tract infections in adults

Women: 100 mg orally every 12 hours for 3 days (for uncomplicated infections).

Men: 100mg orally every 12 hours for at least 14 days.

Prophylaxis against urinary tract infections in children

50 mg orally at night.

Contraindications

Patients with impaired renal function.

Adverse effects

Nitrofurantoin is generally well tolerated at the doses used. The most frequently reported adverse effect is nausea. If doses of 100 mg every 6 hours are used, gastrointestinal symptoms may be more severe.

Peripheral neuritis, pulmonary reactions, hepatotoxicity and haematological changes have been reported.

Storage

Tablets should be stored in well-closed containers.

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