The study is divided into four main parts. The first part provides a brief background on the debate about patents and access to medicines in developing countries as well as an overview of the public health-related TRIPS flexibilities. The second part then identifies the constraints that developing countries face in their efforts to use TRIPS flexibilities for the promotion and protection of public health. The third part analyses, assesses and considers various possibilities for utilizing south-south regional frameworks to overcome the identified constraints in the use of TRIPS flexibilities for public health purposes. Finally, the fourth part draws some conclusions and summarizes the various recommendations made in the study on how developing countries can utilize regional cooperation mechanisms in the South to enhance their capacities to use TRIPS flexibilities for public health promotion and protection.