The Quality of Antimalarials - A Study in Selected African Countries - EDM Research Series No. 030
(2003; 67 pages) View the PDF document
Table of Contents
View the documentAuthors
View the documentCountry Research Team Leaders
View the documentLaboratory Support
View the documentAcknowledgements
View the documentAcronyms
View the documentExecutive summary
View the document1. Background
Close this folder2. Methodology
Open this folder and view contents2.1 Analytical methods
Close this folder2.2 Dissolution testing
View the document2.2.1 Dissolution method for chloroquine tablets
View the document2.2.2 Dissolution method for sulphadoxine/pyrimethamine tablets
View the document3. Results
Open this folder and view contents4. Discussion
Open this folder and view contents5. Conclusions and recommendations
View the documentReferences
Open this folder and view contentsTables
Open this folder and view contentsAnnexes
View the documentOther documents in the EDM Research Series
View the documentEDM Research Series No. 30
 

2.2.2 Dissolution method for sulphadoxine/pyrimethamine tablets

The dissolution parameters for sulphadoxine/pyrimethamine tablets (USP 24) were as follows:

Apparatus:

Apparatus 2 of the USP

Stir rate:

75 rpm

Dissolution medium:

1000 ml phosphate buffer (pH 6.8)

Q-value:

60%

Time:

30 minutes

Sample volume:

2 ml

Six tablets were introduced into the dissolution vessels. Samples (2ml) of the dissolution media in the different vessels were withdrawn after 30 minutes and without any further dilution, analysed for sulphadoxine and pyrimethamine content according to the HPLC method described in the USP for dissolution testing of these tablets. The amount of sulphadoxine and pyrimethamine dissolved after 30 minutes is expressed as a percentage of the label claim.

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