The Quality of Antimalarials - A Study in Selected African Countries - EDM Research Series No. 030
(2003; 67 pages) View the PDF document
Table of Contents
View the documentAuthors
View the documentCountry Research Team Leaders
View the documentLaboratory Support
View the documentAcknowledgements
View the documentAcronyms
View the documentExecutive summary
View the document1. Background
Close this folder2. Methodology
Open this folder and view contents2.1 Analytical methods
Close this folder2.2 Dissolution testing
View the document2.2.1 Dissolution method for chloroquine tablets
View the document2.2.2 Dissolution method for sulphadoxine/pyrimethamine tablets
View the document3. Results
Open this folder and view contents4. Discussion
Open this folder and view contents5. Conclusions and recommendations
View the documentReferences
Open this folder and view contentsTables
Open this folder and view contentsAnnexes
View the documentOther documents in the EDM Research Series
View the documentEDM Research Series No. 30
 

2.2.1 Dissolution method for chloroquine tablets

The dissolution parameters for chloroquine tablets (USP 24) were as follows:

Apparatus:

Apparatus 2 of the USP

Stir rate:

100 rpm

Dissolution medium:

900 ml water

Q-value:

75%

Time:

45 minutes

Sample volume:

5 ml

Six tabletsa were introduced into the dissolution vessels. Samples (5ml) of the dissolution media in the different vessels were withdrawn after 45 minutes and after further dilution, analysed for chloroquine content according to the prescribed UV spectrophotometric method in the USP for the dissolution testing of chloroquine phosphate tablets. The amount of chloroquine dissolved after 45 minutes is expressed as a percentage of the label claim.

a Where fewer than six tablets were available, at least three were analysed for dissolution in order to indicate trends

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