WHO Expert Committee on Drug Dependence – WHO Technical Report Series, No. 915 – Thirty-third Report
(2003; 31 pages) [French] [Spanish] View the PDF document
Table of Contents
View the document1. Introduction
View the document2. Scheduling criteria
Open this folder and view contents3. Critical review of psychoactive substances
Close this folder4. Pre-review of psychoactive substances
View the document4.1 Ketamine (INN)
View the document4.2 Zaleplon (INN)
View the document4.3 Zopiclone (INN)
View the document4.4 Butorphanol (INN)
View the document4.5 Oripavine
View the document4.6 Khat
View the document5. Terminology used in reporting abuse-related adverse drug reactions
View the document6. Other matters
View the documentAcknowledgements
View the documentReferences
View the documentAnnex Terminology used in reporting abuse-related adverse drug reactions

4. Pre-review of psychoactive substances

The review of psychoactive substances by WHO is carried out in two steps. The first step is referred to as pre-review; this is a preliminary review carried out by the Committee to determine whether or not a fully documented review (critical review) of the substance is required. The criterion for judgement of whether critical review is necessary is whether or not WHO has information that may justify the scheduling of the substance. In the case of psychotropic substances, this requires information on actual abuse of the drug causing significant public health and social problems in more than one country.

In addition to the Secretariat, any member of the Expert Committee or any representative of the other organizations invited to participate in the Expert Committee meeting can submit a proposal to pre-review a substance together with supporting information. At the present meeting, ketamine, zalepron and zopiclone were proposed by the Secretariat while butorphanol and khat were proposed by a Member of the Committee. The representative of the International Narcotics Control Board proposed oripavine.

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