Drug and Therapeutics Committees - A Practical Guide
(2003; 155 pages) [French] [Spanish] View the PDF document
Table of Contents
View the documentAcronyms and abbreviations
View the documentPreface
Open this folder and view contents1. Introduction
Open this folder and view contents2.Structure and organization of a drug and therapeutics committee
Open this folder and view contents3. Managing the formulary process
Open this folder and view contents4.Assessing new medicines
Open this folder and view contents5.Ensuring medicine safety and quality
Close this folder6.Tools to investigate the use of medicines
View the document6.1 Stepwise approach to investigating the use of medicines
View the document6.2 Analysis of aggregate medicine use data
View the document6.3 WHO/INRUD drug use indicators for health facilities
View the document6.4 Qualitative methods to investigate causes of problems of medicine use
View the document6.5 Drug use evaluation (DUE) (drug utilization review)
View the documentAnnex 6.1 Defined daily doses (DDD) of some common medicines
View the documentAnnex 6.2 DUE criteria on data collection form for amikacin
Open this folder and view contents7.Promoting the rational use of medicines
Open this folder and view contents8.Antimicrobials and injections
Open this folder and view contents9. Getting started
View the documentGlossary1
View the documentReferences
View the documentFurther reading
View the documentUseful addresses and websites
View the documentBack cover
 

Annex 6.1 Defined daily doses (DDD) of some common medicines

Drug name

DDD

Preoperative medication

 

atropine sulfate

1.5 mg

diazepam (inj, oral, rect)

10 mg

morphine sulfate

0.1 g

promethazine hcl

25 mg

Analgesics and NSAIDs

 

acetylsalicylic acid

3 g

diclofenac sodium

0.1 g

ibuprofen

1.2 g

indomethacin

0.1 g

naproxen

0.5 g

paracetamol

3 g

pheylbutazone

0.3 g

Opioids

 

codeine

0.1 g

morphine sulfate

0.1 g

pentazocine

0.2 g

pethidine

0.4 g

tramadol

0.3 g

Gout

 

allopurinol

0.4 g

colchicine

1 mg

probenecid

1 g

Rheumatoid disease

 

azathioprine

0.15 g

chloroquine

0.5 g

Antiallergics

 

astemizole

10 mg

chlorpheniramine

12 mg

dexamethasone

1.5 mg

diphenhydramine

0.3 g

epinephrine

0.5 mg

hydrocortisone

30 mg

prednisolone

10 mg

Drug name

DDD

Anticonvulsants

 

carbamazepine

1 g

diazepam

10 mg

ethosuximide

1.25 g

magnesium sulfate

3 g

phenobarbital

0.1 g

phenytoin

0.3 g

valproic acid

1.5 g

clonazepam

8 mg

Anthelmintics

 

albendazole

0.4 g

levamisole

0.15 g

mebendazole

0.2 g

niclosamide

2 g

piperazine

3.5 g

praziquantel

3 g

pyrantel

0.75 g

thiabendazole

3 g

Antianginal drugs

 

atenolol

75 mg

glyceryl trinitrate

5 mg

isosorbide dinitrate

60 mg

nifedipine

30 mg

Antiarrhythmics

 

isoprenaline inj

90 mg

lidocaine

3 g

procainamide

3 g

propranolol

0.16 g

quinidine sulfate

1.2 g

verapamil

0.24 g

Antihypertensives

 

atenolol

75 mg

captropril

50 mg

enalapril

10 mg

hydralazine

0.1 g

hydrochlorothiazide

50 mg

Drug name

DDD

methyldopa

1 g

nifedipine

30 mg

nitroprusside, sodium

50 mg

prazocin

5 mg

reserpine

0.5 mg

Heart failure drugs

 

digoxin

0.25 mg

dopamine

0.5 g

epinephrine

0.5 mg

Diuretics

 

amiloride

10 mg

bendrofluazide

2.5 mg

frusemide

40 mg

hydrochlorothiazide

50 mg

spironolactone

75 mg

Antithrombotics

 

streptokinase

1.5 MU

Anticoagulants

 

desmopressin (inj)

4.0 mcg

desmopressin (oral)

0.4 mg

desmopressin (nasal)

25 mcg

heparin

10 TU

vitamin K-phytomenadione

20 mg

warfarin sodium

7.5 mg

Anti-infectives

 

albendazole

0.4 g

diethylcarbamazine

0.4 g

ivermectin

12 mg

Antischistosomals

 

oxamniquine

1 g

praziquantel

3 g

Beta-lactams

 

amoxycillin

1 g

ampicillin

2 g

ceftazidime

6 g

cetriaxone

2 g

cephazolin

3 g

cefotaxime

4 g

cefuroxime

2 g

cephalexin

2 g

cephazolin

3 g

cloxacillin sodium

2 g

methicillin

4 g

imipenem

2 g

pencillin G sodium

3.6 g

pencillin V

2 g

Other antibacterials

 

chloramphenicol

3 g

ciprofloxacin

1 g

clindamycin

1.2 g

doxycycline

0.1 g

erythromycin

1 g

gentamicin sulfate

0.24 g

kanamycin sulfate

1 g

metronidazole (inj/oral)

1.5 g

metronidazole pessary

0.5 g

nalidixic acid

4 g

nitrofurantoin

0.2 g

norfloxacin

0.8 g

oxytetracycline

1 g

spectinomycin

3 g

sulfadiazine

0.6 g

sulfadimidine

4 g

tetracycline

1 g

trimethoprim

0.4 g

vancomycin

2 g

Antileprosy drugs

 

clofazimine

0.1 g

dapsone

0.05 g

rifampicin

0.6 g

Antituberculosis drugs

 

ethambutol

1.2 g

isoniazid

0.3 g

pyrazinamide

1.5 g

rifampicin

0.6 g

streptomycin sulfate

1 g

Antacids/peptic ulcer

 

magnesium hydroxide

3 g

cimetidine

0.8 g

famotidine

40 mg

ranitidine

0.3 g

omeprazole

20 mg

Antiemetics

 

metoclopramide

30 mg

promethazine

25 mg

Antispasmodics

 

atropine sulfate

1.5 mg

propantheline bromide

60 mg

Laxatives

 

bisacodyl (suppos./oral)

10 mg

liquid paraffin

15 g

Antidiarrhoeals

 

codeine

0.1 g

loperamide

10 mg

sulfaguanidine

4 g

Hormones/contraceptive

 

clomiphene

9 mg

ethinyl oestradiol

25 mcg

norethisterone

5 mg

medroxyprogesteron oral

5 mg

Insulins/antidiabetics

 

chlorpropamide

0.375 g

glibenclamide

10 mg

insulins - all types

40 IU

metformin

2 g

tolbutamide

1.5 g

Thyroid/antithyroid

 

carbimazole

15 mg

levothyroxine

0.15 mg

propylthiouracil

0.1 g

Miotics/antiglaucoma

 

acetazolamide oral

0.75 g

pilocarpine drops-2% 4%

0.4 mL

timolol mal.- 0.25% 0.5%

0.2 mL

Antitussives

 

dextromethorphan

90 mg

diphenhydramine

0.3 g

noscapine

0.125 g

Antifungals

 

amphotericin B

35 mg

clotrimazole (pessary)

0.1 g

fluconazole

0.2 g

flucytosine

10 g

griseofulvin

0.5 g

ketoconazole

0.2 g

nystatin (oral)

1.5 MU

nystatin (pessary)

0.1 MU

Antiretrovirals

 

aclyclovir

4 g

zidovudine

0.6 g

Antiprotozoals

 

diloxanide furoate

1.5 g

metronidazole (oral/inj)

1.5 g

tinidazole

1.5 g

Antileishmaniasis

 

meglumine antimonate

0.85 g

pentamidine

0.28 g

sodium stibogluconate

0.85 g

Antimalarials

 

chloroquine phosphate

0.5 g

doxycycline

0.1 g

mefloquine

1 g

primaquine phosphate

15 mg

proguanil

0.2 g

pyrimethamine

75 mg

quinine dihydrochloride

0.3 g

quinine sulfate

0.3 g

sulfadoxine/pyrimeth.

75 mg

African trypanosomiasis

 

metronidazole oral

1.5 g

melarsoprol

60 mg

suramin sodium

0.27 g

American trypanosomiasis

 

benznidazole

0.4 g

nifurtimox

0.7 g

Immunosuppressives

 

azathioprine

0.15 g

Antihormones

 

tamoxifen

20 mg

Adrenal hormones

 

dexamethasone (oral/inj)

1.5 mg

hydrocortisone (inj)

30 mg

prednisolone (oral/inj)

10 mg

Antiparkinsonism

 

biperidin

10 mg

levodopa + carbidopa

0.6 g

Antianaemia

 

ferrous salt (iron = 60 mg)

0.2 g

folic acid

0.3 mg

hydroxycobalamin

0.02 mg

Oxytoxics/antioxytoxic

 

ergometrine maleate

0.2 mg

ergotamine tartrate

4 mg

oxtocin (inj)

15 IU

Psychotherapeutics

 

amitriptyline

75 mg

chlorpromazine (inj)

0.1 g

chlorpromazine (oral)

0.3 g

clomipramine

0.1 g

diazepam (oral)

10 mg

fluphenazine (inj)

1 mg

haloperidol (inj)

3.3 mg

haloperidol (oral)

8 mg

imipramine

0.1 g

lithium carbonate (oral)

24mmol

lorazepam

2.5 mg

nitrazepam

5 mg

thioridazine

0.3 g

trifluoperazine oral

20 mg

Antiasthmatics

 

aminophylline inj/oral

0.6 g

beclomethasone inhaler

0.8 mg

cromoglycic acid inhaler

40 mg

ephedrine

50 mg

epinephrine (inj)

0.5 mg

ipatropium inhaler

0.12 mg

salbutamol (inj/oral)

12 mg

salbutamol inhaler

0.8 mg

salbutamol respsol

10 mg

theophylline

0.4 g

Vitamins/minerals

 

ascorbic acid (vit.C)

0.2 g

calcium gluconate

3 g

calcium lactate

2 g

nicotinamide/niacin (vitamin B3)

0.15 g

potassium chloride

3 g

pyridoxine (vitamin b6)

0.16 g

thiamine (vitamin B1)

50 MG

retinol (vitamin A)

5000 IU

Muscle relaxants

 

neostigmine (inj)

60 mg

pyridostigmine (inj)

10 mg

The drugs listed here are a selection of medicines taken from WHO’s Model list of essential medicines (WHO 2002a) and MSH’s annual International drug price indicator guide, presented according to therapeutic category. The information presented here was correct at the time of going to press, but may have changed since. This list is not exhaustive, nor is it intended to be, in any way, a recommendation for inclusion in national or hospital formulary lists. The DDD for different drugs can be obtained from:

WHO Collaborating Centre for Drug Statistics Methodology, Postboks 100 Veitvet, Oslo, Norway (http://www.whocc.no) Tel. +47 22 16 98 11; Fax: +47 22 16 98 18; email: whocc@nmd.no

Management Sciences for Health (MSH), International drug price indicator guide, annual publication by MSH in collaboration with WHO, 165 Allandale Road, Boston, MA 02130-3400, USA (http://www.msh.org/publications and http://erc.msh.org). Tel. +1 617 524 7799; Fax: +1 617 524 2825; email: bookstore@msh.org

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Last updated: May 3, 2013