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pharmaceutical substances
WHO Pharmaceuticals Newsletter 1999, No. 09&12
(1999; 30 pages)
Table of Contents
Regulatory actions
Amineptine - marketing authorization suspended: Morocco
Anorectic agents - withdrawal of marketing authorizations recommended: EC, Portugal
Colloidal silver or silver salts - final rule: no longer acceptable in over-the- counter products: USA
Epinephrine injections (Ana-Kit and Ana-Guard) - withdrawn: USA
Flutamide - warning concerning severe hepatic dysfunction: Schering, USA
Medifoxamine - withdrawn: hepatotoxicity: France
New variant CJD - new precautionary measures to reduce risk from blood products: USA
Pimozide - warning concerning sudden deaths: Gate Pharmaceuticals, USA
Pseudoephedrine and phenylpropanolamine - restricted use: Morocco
Salbutamol - recall of defective lot: Warrick Pharmaceuticals, USA
Terfenadine - withdrawn from the market: cardiac arrhythmias: Morocco
Trovafloxacin - restricted use: Morocco
Vectorex and Scalarex - illegal sale: Belgium
Drug surveillance
Alendronic acid - oesophagitis and musculoskeletal problems: Australia
Botulinum toxin - more effective than nitrates for treating chronic anal fissures: Italy
Dicloxacillin and flucloxacillin - comparison of adverse reactions: Australia
Drug-induced gingival overgrowth - review of reports: Australia
Fluoroquinolones - tendinitis: update: Australia
Folic acid deficiency - possible link with Down’s syndrome: USA
Interferon alfa - depression: Australia
Measles/mumps/rubella (MMR) vaccine - new studies confirm lack of evidence of link with inflammatory bowel disease and/or autism: UK
Miconazole (intravaginal) - increased anticoagulant effect: Netherlands
Olanzapine - neutropenia, convulsions and neuroleptic malignant syndrome: Australia
Spironolactone - positive results in patients with severe heart failure: USA
Terbinafine - review of severe adverse reactions: Morocco
Warfarin brands Coumadin and Marevan - not interchangeable: Australia
New developments
Antihaemophilic factor/von Willebrand Factor Complex (human) - approved for severe cases of von Willebrand’s disease: USA
Oseltamivir - approved for influenza: USA
Pemirolast - approved in allergic conjunctivitis: USA
Pioglitazone - approved for adult-onset diabetes: USA
Quinupristin/dalfopristin - approved for certain vancomycin-resistant infections: USA
Sirolimus - approved for prevention of organ rejection: USA
Zanamivir (inhalation) - approved for treatment of influenza: USA
New indications
New formulations
Newly approved products
Medical devices
Dental amalgams containing mercury - review: France
Endoscopes - infections due to inadequate reprocessing: USA
Endovascular grafts - two new devices approved for aneurysm repair: USA
HIV Rapid Home-Use test kits: warning - unapproved device sold on the Internet: USA
Pneumonia antigen test - quick new lab test approved: USA
Silicone inflatable breast prosthesis - requirement for premarket approval: USA
Vascular haemostasis devices - complications: USA
Medication errors
Automated dispensing devices - survey shows need for practical improvements and safe system design: USA
Hespan and heparin - errors due to name confusion: USA
Long-acting parenteral penicillins
(1) Bicillin C-R versus Bicillin - inadvertent use in syphilis: USA
(2) Benzylpenicillin (Bicillin C-R) - erroneously administered intravenously: USA
Medication delivery devices - errors due to lack of focus on human factors: USA
Paracetamol paediatric liquid formulations - container redesigned to avoid errors: USA
Xenical and Xeloda - name confusion: Roche, USA
General information
Advertising of prescription medicines - direct-to-consumer advertising: USA
Bloodborne pathogen assays to test donors - guidance available: recommendations for the invalidation of test results: USA
Osteoporosis - guidelines available: UK
Oxygen therapy - guidelines available: UK
Prescribing in the elderly - national audit: UK
Veterinary medicine
Adverse reactions to animal medicines - reporting: UK
Nandrolone injection - off-licence use reported in ewes: UK
WHO Pharmaceuticals Newsletter 1999, No. 09&12
Essential Drugs and Medicines Policy
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Last updated: May 3, 2013
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