Germany. Following the worldwide withdrawal of products containing the muscle relaxant chlormezanone (TrancopalR) by the manufacturer Sanofi Winthrop and subsequent similar action by generic manufacturers, the Federal Institute of Drugs and Medical Devices has now withdrawn the marketing authorization for all medicinal products containing chlormezanone. These action were taken after a risk of severe cutaneous reactions and hepatotoxicity was identified in association with the use of chlormezanone. No products now remain on the market.
[See also Pharmaceuticals Newsletter Nos. 1&2, January & February 1997 and Alert No. 53 dated 18 October 1996]
Reference: Pharmazeutische Zeitung Vol. 142(44): 3908 (1997).