(1998; 18 pages)
Selective serotonin reuptake inhibitors (SSRIs) - neonatal disorders
Australia. The Adverse Drug Reactions Advisory Committee has received several reports of effects on the neonate associated with the use of selective serotonin reuptake inhibitors (SSRIs), including fluoxetine, fluvoxamine, paroxetine and sertraline.
Four reports describe withdrawal reactions in neonates whose mothers had taken SSRIs throughout their pregnancies. These reactions were generally characterized by tachypnoea, irritability, jitteriness, fever anorexia, cyanosis and possibly convulsions. The effects in all four cases appeared to resolve spontaneously.
Another four reports relate to probable breast milk transfer since they all refer to breast-fed babies. These reports include one case of hyperglycaemia and glycosuria; two cases of agitation and one case in which the baby became somnolent, with low muscle tone, hearing problems and suspected developmental difficulties.
Reference: Australian Adverse Drug Reactions Bulletin 16(4): 14 (1997).