WHO Pharmaceuticals Newsletter 1998, No. 03&04
(1998; 18 pages)
Table of Contents
Open this folder and view contentsRegulatory actions
Close this folderDrug surveillance
View the documentAcetylsalicylic acid and NSAIDs - OTC availability: increased potential for adverse reactions
View the documentDrug-induced depression - review
View the documentMidazolam - paradoxical reactions in children
View the documentSelective serotonin reuptake inhibitors (SSRIs) - neonatal disorders
View the documentSumatriptan - fatal outcomes
View the documentVenlafaxine - review of adverse reactions
Open this folder and view contentsNew developments
View the documentRecent approvals
Open this folder and view contentsMedical devices
Open this folder and view contentsGeneral information
Open this folder and view contentsVeterinary medicine

Midazolam - paradoxical reactions in children

Australia. The Adverse Drug Reactions Advisory Committee has received 31 reports associated with the use of midazolam as a sedative or premedication for anaesthesia that describe paradoxical reactions such as agitation (18), aggression (11), abnormal crying (9), hallucinations (7) or emotional lability (3).

Twenty of these cases occurred in children 11 years of age and younger. All of the children recovered, usually after an hour or two, although in two cases the benzodiazepine antagonist flumazenil was used.

Reference: Australian Adverse Drug Reactions Bulletin 17(1): 2 (1998).

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