(1999; 58 pages)
Group: antidote to folinic acid antagonists
Tablet, 5 mg, 15 mg [EDL]
Calcium folinate is a metabolically active, reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives.
To decrease the haematopoetic toxicity of pyrimethamine and other inhibitors of folic acid metabolism in patients with HIV infection.
Dosage and administration
Adults and children: 5-50 mg/day dose adjusted according to patients blood counts.
The possibility of pernicous anaemia should always be excluded before starting treatment with calcium folinate. Its use obscures the diagnosis by rectifying the characteristic megaloblastic anaemia but it does not prevent neurological damage.
Use in pregnancy
Calcium folinate should always be used when pyrimethamine and sulfonamides are administered during pregnancy.
Calcium folinate is generally well-tolerated. Rarely, hypersensitivity reactions occur, including urticaria, rash and pruritus.
Tablets should be stored in tightly closed containers protected from light.