Stability of Injectable Oxytocics in Tropical Climates: Results of Field Surveys and Simulation Studies on Ergometrine, Methylergometrine and Oxytocin - EDM Research Series No. 008
(1993; 50 pages)

Table of Contents

Summary
Introduction
	Outline of the study
	Acknowledgments
Materials and methods
	Sampling methods
	Temperature and light conditions, time interval
	Laboratory analysis
Results
	Field research
	Simulation study
Discussion
	Field research
	Pattern of stability of common injectable oxytocics
		Ergometrine
		Methylergometrine
		Oxytocin
		Influence of light
		Short exposure to high temperature
		Hypothetical loss of active ingredient in tropical climates
	Selection of the most Stable injectable oxytocic
	Relation between colour and level of (methyl)ergometrine
	Oxygen content and pH
Conclusions and recommendations
References
Annexes
	Annex 1: Results of field studies on ergometrine injection
	Annex 2: Results of field studies on oxytocin injection
	Annex 3: Results of simulation studies
	Annex 4: Summary results of simulation studies
	Annex 5: Stability of (methyl) ergometrine injection (dark versus light)
	Annex 6: Comparison ergometrine vs. methylergometrine injection (2 brands each)

Stability of Injectable Oxytocics in Tropical Climates: Results of Field Surveys and Simulation Studies on Ergometrine, Methylergometrine and Oxytocin - EDM Research Series No. 008

	Action Programme on Essential Drugs
	Safe Motherhood Research Programme

WHO/DAP/93.6
Original: English
Distr.: Limited

H.V. Hogerzeil, WHO Action Programme on Essential Drugs
G.J.A. Walker, WHO Maternal Health and Safe Motherhood Research
M.J. de Goeje, International Dispensary Association, Amsterdam