Pharmaceuticals: Restrictions in Use and Availability
(2001; 40 pages) View the PDF document
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View the documentAlatrofloxacin mesilate
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Open this folder and view contentsCombination Products
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Dantron

Product name:

Dantron

CAS number:

117-10-2

Synonyms:

Danthron, Antrapurol, Chrysazin, Dianthon

Country

Effective Date

Description of action taken
Grounds for decision

Canada

November 1997

After reviewing the benefits and risks associated with the use of dantron-containing stimulant laxatives, Health Canada has concluded that dantron is a genotoxic animal carcinogen and that the risks of using these products outweigh the therapeutic benefits. Dantron is a synthetic anthraquinone and, although there is no direct evidence that it has caused cancer in humans, it may have a carcinogenic potential. Manufacturers have voluntarily ceased sale of their products. (Reference: Press Release 1997-64, 25 November 1997.)

United Kingdom

May 2000

The Medicines Control Agency has severely restricted the use of the laxative, dantron following studies showing genotoxicity. It is now restricted to use in terminally ill adult patients only. (Reference: Communication to WHO, 30 August 2000 from the Medicines Control Agency, Department of Health, United Kingdom.)

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