Zimbabwe - The Medicines Control Authority has recently received four adverse reaction reports of "burn-like lesions on the whole body and mucosal ulcerations" associated with isoniazid and rifampicin. None of the four patients were taking concomitant medicines. All patients recovered.

It was noted from records at the WHO Collaborating Centre for International Drug Monitoring that since 1993 the Authority had received seven reports of skin reactions (rash, pruritus) associated with rifampicin and isoniazid. Five of the seven reports indicated that the patients were also taking ethambutol and pyrazinamide.

Reference: Drug Information Bulletin, Vol. 4, No. 2, June 2000.