Many societal and health system factors, as well as professionals and many others, contribute to how medicines are used, Therefore, a multi-disciplinary approach is needed to develop, implement and evaluate interventions to promote more rational use of medicines. A national regulatory authority (RA) is the agency that develops and implements most of the legislation and regulation on pharmaceuticals, Ensuring rational use will require many additional activities which will need coordination with many stakeholders, Thus a national body is needed to coordinate policy and strategies at national level, in both the public and private sectors, The form this body takes may vary with the country, but in all cases it should involve government (ministry of health), the health professions, academia, the RA, pharmaceutical industry, consumer groups and non-governmental organizations involved in health care, The impact on medicine use is better if many interventions are implemented together in a coordinated way, single interventions often having little impact.