Australia. Since late 2000, the Australian Adverse Reactions Advisory Committee (ADRAC) has received 8 reports of increased International Normalised Ratio (INR) in patients simultaneously using rofecoxib and warfarin. Of these, 2 reports described bleeding events (epistaxis and rectal haemorrhage) and 1 described anaemia. The committee recommends increased monitoring of INR in patients taking warfarin and concomitant rofecoxib.

Reference:

Australian Adverse Drug Reactions Bulletin 21(1): 3, Feb 2002.