WHO Drug Information Vol. 16, No. 1, 2002
(2002; 116 pages) View the PDF document
Table of Contents
View the documentPreface
Open this folder and view contentsVaccines and Biomedicines
Close this folderSafety Information
View the documentWHO international drug monitoring: cerivastatin and gemfibrozil
View the documentInternational Conference on Harmonization (ICH): pharmacovigilance activities
View the documentThe COX-2 inhibitors
View the documentAmiodarone and pulmonary toxicity
View the documentAlendronate: link with pancreatitis?
View the documentEndocrinotoxicity induced by Coriandrum sativa: a case report
View the documentHaemolysis after consumption of Viola tricolor
View the documentLipodystrophy syndrome under-reported
Open this folder and view contentsCurrent Topics
Open this folder and view contentsRegulatory and Safety Action
Open this folder and view contentsQuality Assurance Issues
Open this folder and view contentsRecent Publications and Sources of Information
View the documentProposed International Nonproprietary Names: List 86
View the documentRecommended International Nonproprietary Names (Rec. INN): List 47
View the documentSelected WHO publications of related interest

Endocrinotoxicity induced by Coriandrum sativa: a case report

Ebrahim Zabihi and Mohammad Abdollahi, Drug and Poisoning Information Center (DPIC), Food and Drug Organization, Ministry of Health & Medical Education, Islamic Republic of Iran

A 28 year old woman had taken an extract of Coriandrum sativa leaves and branches (200 ml of about 10% aqueous extract for 7 executive days) to augment lactation to breastfeed her 10-month-old infant. After 7 days she was admitted to the hospital with severe diarrhoea and stomach pain. The patient had no significant serum or urine test changes and recovered after common palliative therapy. Fifteen days later the patient came back complaining of skin darkness, depressed mood and loss of body fluids and amenorrhoea, which was diagnosed as an adrenal dysfunction. The patient said that she did not have any history of such a condition. The patient received intramuscular dexamethasone (4 mg/day) for 3 days then continued with pred-nisolone tablet (5 mg/day) for 10 consecutive days. She also received oral contraceptive for relief of her menstruation cycle disturbances (spotting, oligomenorrhoea, dysmenorrhoea). After 10 days the patient was well and healthy.

Based on the literature, coriander seeds have been used as a herbal medicine (3 g/day) as antispasmodic and anticarminative (1, 2). Also its leaves and small branches are used as a vegetable and food supplement in Iran (3).


1. Blumenthal, M., Goldberg, A., Brinckmann. Journal of Integrative Medicine, 75-76 (2000).

2. Weis, R.F., Fintelmann, V. Herbal Medicine, 2nd ed., Thieme, 2000 pp. 77-78.

3. Zargari, A. Herbal Drugs, Teheran University Publication Inc., 13774, Vol. 2, 586-587.

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