Canada - Accidental oral ingestion of brimonidine ophthalmic drops (about 2 mL) in a 28-month-old child caused decreased consciousness and apnea resulting in intubation, ventilation and surveillance in an intensive care unit for 40 hours. Recommendations for child-resistant packaging were made to the manufacturer. As an immediate option to reduce the risk of accidental exposure, consider dispensing these ophthalmic drops in childproof vials.

Reference: Canadian Adverse Drug Reaction Newsletter, Volume 11(4) on http://www.hc-sc.gc.ca/hpb-dgps/therapeut/zfiles/