A large proportion of gonococcal isolates worldwide are now resistant to penicillins, tetracyclines, and other older antimicrobial agents, which can therefore no longer be recommended for the treatment of gonorrhoea.

It is important to monitor local in vitro susceptibility, as well as the clinical efficacy of recommended regimens.

Note

In general it is recommended that concurrent anti-chlamydia therapy be given to all patients with gonorrhoea, as described in the section on chlamydia infections, since dual infection is common. This does not apply to patients in whom a specific diagnosis of C. trachomatis has been excluded by a laboratory test.