- Keywords > Clinical Practice Guidelines (CPGs)
- Keywords > criteria of medicines selection
- Keywords > HIV infection and STIs
- Keywords > opportunistic infections and other HIV-related
- Keywords > reproductive tract infections
- Keywords > sexual and reproductive health
- Keywords > sexually transmitted infections (STIs)
- Keywords > treatment guidelines
- Keywords > treatment protocols
(2004; 88 pages)
3.6. Granuloma inguinale (Donovanosis)
Donovanosis is caused by the intracellular Gram-negative bacterium Calymmatobacterium granulomatis. The disease presents clinically as painless, progressive, ulcerative lesions without regional lymphadenopathy. The lesions are highly vascular and can easily bleed on contact. Treatment should be continued until all lesions have completely epithelialized.
• azithromycin, 1g orally on first day, then 500mg orally once a day
• doxycycline, 100mg orally, twice daily
• erythromycin, 500mg orally, 4 times daily
• tetracycline, 500mg orally, 4 times daily
• trimethoprim (80mg)/sulfamethoxazole (400mg), 2 tablets orally, twice daily for a minimum of 14 days,
The addition of a parenteral aminoglycoside such as gentamicin should be strongly considered for HIV-infected patients.
Patients should be followed clinically until signs and symptoms have resolved.