- Keywords > Clinical Practice Guidelines (CPGs)
- Keywords > criteria of medicines selection
- Keywords > HIV infection and STIs
- Keywords > opportunistic infections and other HIV-related
- Keywords > reproductive tract infections
- Keywords > sexual and reproductive health
- Keywords > sexually transmitted infections (STIs)
- Keywords > treatment guidelines
- Keywords > treatment protocols
(2004; 88 pages)
Owing to widespread resistance in all geographical areas, tetracycline and penicillins have no place in the treatment of chancroid. Single-dose therapy with anti-microbials are the preferred regimen.
• ciprofloxacin, 500mg orally, twice daily for 3 days
• erythromycin base, 500mg orally, 4 times daily for 7 days
• azithromycin, 1g orally, as a single dose.
• ceftriaxone, 250mg by intramuscular injection, as a single dose
Management of lesions
No special treatment is required. Ulcerative lesions should be kept clean, and fluctuant lymph nodes should be aspirated as required through the surrounding healthy skin. Incision and drainage or excision of nodes may delay healing and is not recommended.
All patients should be followed up until there is clear evidence of improvement or cure. In patients infected with HIV, treatment may appear less effective, but this may be due to co-infection with genital herpes or syphilis. Since chancroid and HIV infection are closely associated and therapeutic failure is likely to be seen with increasing frequency, patients should be followed up weekly until there is clear evidence of improvement.