- Keywords > Clinical Practice Guidelines (CPGs)
- Keywords > criteria of medicines selection
- Keywords > HIV infection and STIs
- Keywords > opportunistic infections and other HIV-related
- Keywords > reproductive tract infections
- Keywords > sexual and reproductive health
- Keywords > sexually transmitted infections (STIs)
- Keywords > treatment guidelines
- Keywords > treatment protocols
(2004; 88 pages)
Syphilis and HIV infection
All patients with syphilis should be encouraged to undergo testing for HIV because of the high frequency of dual infection and its implications for clinical assessment and management. Neurosyphilis should be considered in the differential diagnosis of neurological disease in HIV-infected individuals. In cases of congenital syphilis, the mother should be encouraged to undergo testing for HIV; if her test is positive, the infant should be referred for follow-up.
Recommended therapy for early syphilis in HIV-infected patients is no different from that in non-HIV-infected patients. However, some authorities advise examination of the cerebrospinal fluid and/or more intensive treatment with a regimen appropriate for all patients with the dual infections of Treponema pallidum and HIV, regardless of the clinical stage of syphilis. In all cases, careful follow-up is necessary to ensure adequacy of treatment.