- Keywords > Clinical Practice Guidelines (CPGs)
- Keywords > criteria of medicines selection
- Keywords > HIV infection and STIs
- Keywords > opportunistic infections and other HIV-related
- Keywords > reproductive tract infections
- Keywords > sexual and reproductive health
- Keywords > sexually transmitted infections (STIs)
- Keywords > treatment guidelines
- Keywords > treatment protocols
(2004; 88 pages)
Late latent syphilis
• benzathine benzylpenicillin, 2.4 million IU by intramuscular injection, once weekly for 3 consecutive weeks.
• procaine benzylpenicillin, 1.2 million IU, by intramuscular injection, once daily for 20 consecutive days.
Alternative regimen for penicillin-allergic non-pregnant patients
• doxycycline, 100mg orally, twice daily for 30 days.
• tetracycline, 500mg orally, 4 times daily for 30 days
Penicillin is the preferred therapy and should be given whenever possible. It should be emphasized that antibiotic treatment is less well defined for late syphilis than it is for early syphilis. In general, late syphilis requires longer therapy.
Consultation with a cardiologist is recommended when caring for patients with cardiovascular syphilis.