Guidelines for the Management of Sexually Transmitted Infections. February 2004
(2004; 88 pages)
Table of Contents
View the documentPREFACE
Open this folder and view contents1. INTRODUCTION
Open this folder and view contents2. TREATMENT OF STI-ASSOCIATED SYNDROMES
Close this folder3. TREATMENT OF SPECIFIC INFECTIONS
Open this folder and view contents3.1. Gonococcal infections
Open this folder and view contents3.2. Chlamydia trachomatis infections (other than lymphogranuloma venereum)
View the document3.3. Lymphogranuloma venereum
Close this folder3.4. Syphilis
View the documentEarly syphilis
View the documentLate latent syphilis
View the documentNeurosyphilis
View the documentSyphilis and HIV infection
View the documentSyphilis in pregnancy
View the documentCongenital syphilis
View the document3.5. Chancroid
View the document3.6. Granuloma inguinale (Donovanosis)
Open this folder and view contents3.7. Genital herpes infections
Open this folder and view contents3.8. Venereal warts
View the document3.9. Trichomonas vaginalis infections
Open this folder and view contents3.10. Bacterial vaginosis
Open this folder and view contents3.11. Candidiasis
View the document3.12. Scabies
View the document3.13. Phthiriasis (pediculosis pubis)
Open this folder and view contents4. KEY CONSIDERATIONS UNDERLYING TREATMENTS
Open this folder and view contents5. PRACTICAL CONSIDERATIONS IN STI CASE MANAGEMENT
Open this folder and view contents6. CHILDREN6, ADOLESCENTS AND SEXUALLY TRANSMITTED INFECTIONS
View the documentANNEX. LIST OF PARTICIPANTS
 

Late latent syphilis

Recommended regimen

• benzathine benzylpenicillin, 2.4 million IU by intramuscular injection, once weekly for 3 consecutive weeks.

Alternative regimen

• procaine benzylpenicillin, 1.2 million IU, by intramuscular injection, once daily for 20 consecutive days.

Alternative regimen for penicillin-allergic non-pregnant patients

• doxycycline, 100mg orally, twice daily for 30 days.

OR

• tetracycline, 500mg orally, 4 times daily for 30 days

Penicillin is the preferred therapy and should be given whenever possible. It should be emphasized that antibiotic treatment is less well defined for late syphilis than it is for early syphilis. In general, late syphilis requires longer therapy.

Consultation with a cardiologist is recommended when caring for patients with cardiovascular syphilis.

to previous section
to next section
 
 
The WHO Essential Medicines and Health Products Information Portal was designed and is maintained by Human Info NGO. Last updated: December 1, 2019