Guidelines for the Management of Sexually Transmitted Infections. February 2004
(2004; 88 pages)
Table of Contents
View the documentPREFACE
Open this folder and view contents1. INTRODUCTION
Open this folder and view contents2. TREATMENT OF STI-ASSOCIATED SYNDROMES
Close this folder3. TREATMENT OF SPECIFIC INFECTIONS
Open this folder and view contents3.1. Gonococcal infections
Close this folder3.2. Chlamydia trachomatis infections (other than lymphogranuloma venereum)
View the documentUncomplicated anogenital, endocervical or rectal infections
View the documentNeonatal chlamydial conjunctivitis
View the documentInfantile pneumonia
View the document3.3. Lymphogranuloma venereum
Open this folder and view contents3.4. Syphilis
View the document3.5. Chancroid
View the document3.6. Granuloma inguinale (Donovanosis)
Open this folder and view contents3.7. Genital herpes infections
Open this folder and view contents3.8. Venereal warts
View the document3.9. Trichomonas vaginalis infections
Open this folder and view contents3.10. Bacterial vaginosis
Open this folder and view contents3.11. Candidiasis
View the document3.12. Scabies
View the document3.13. Phthiriasis (pediculosis pubis)
Open this folder and view contents4. KEY CONSIDERATIONS UNDERLYING TREATMENTS
Open this folder and view contents5. PRACTICAL CONSIDERATIONS IN STI CASE MANAGEMENT
Open this folder and view contents6. CHILDREN6, ADOLESCENTS AND SEXUALLY TRANSMITTED INFECTIONS
View the documentANNEX. LIST OF PARTICIPANTS
 

Uncomplicated anogenital, endocervical or rectal infections

Recommended regimens

• doxycycline, 100mg orally, twice daily for 7 days

OR

• azithromycin, 1g orally, in a single dose

Alternative regimens

• amoxycillin, 500mg orally, three times a day for 7 days

OR

• erythromycin, 500mg orally, four times a day for 7 days

OR

• ofloxacin, 300mg orally, twice a day for 7 days

OR

• tetracycline, 500mg orally, four times a day for 7 days.

Note

• Doxycycline (and other tetracyclines) are contraindicated during pregnancy and lactation.

• Current evidence indicates that 1 gram single dose therapy of azithromycin is efficacious for chlamydia infection.

There is evidence that extending the duration of treatment beyond 7 days does not improve the cure rate in uncomplicated chlamydia infection. Erythromycin should not be taken on an empty stomach.

Follow-up

Compliance with the 7-day regimens is critical. Resistance of C. trachomatis to recommended treatment regimens has not been observed.

CHLAMYDIAL INFECTION IN PREGNANCY

Recommended regimens

• erythromycin, 500mg orally four times a day for 7 days

OR

• amoxycillin, 500mg orally three times a day for 7 days.

Note

• Doxycycline (and other tetracyclines) and ofloxacin are contraindicated in pregnant women. The safety and efficacy of azithromycin use in pregnant and lactating women have not been established.

• Erythromycin estolate is contraindicated during pregnancy because of drug-related hepato-toxicity so only erythromycin base or erythromycin ethylsuccinate should be used.

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