Guidelines for the Management of Sexually Transmitted Infections. February 2004
(2004; 88 pages)
Table of Contents
View the documentPREFACE
Open this folder and view contents1. INTRODUCTION
Open this folder and view contents2. TREATMENT OF STI-ASSOCIATED SYNDROMES
Close this folder3. TREATMENT OF SPECIFIC INFECTIONS
Close this folder3.1. Gonococcal infections
View the documentUncomplicated anogenital infection
View the documentDisseminated infection
View the documentGonococcal ophthalmia
Open this folder and view contents3.2. Chlamydia trachomatis infections (other than lymphogranuloma venereum)
View the document3.3. Lymphogranuloma venereum
Open this folder and view contents3.4. Syphilis
View the document3.5. Chancroid
View the document3.6. Granuloma inguinale (Donovanosis)
Open this folder and view contents3.7. Genital herpes infections
Open this folder and view contents3.8. Venereal warts
View the document3.9. Trichomonas vaginalis infections
Open this folder and view contents3.10. Bacterial vaginosis
Open this folder and view contents3.11. Candidiasis
View the document3.12. Scabies
View the document3.13. Phthiriasis (pediculosis pubis)
Open this folder and view contents4. KEY CONSIDERATIONS UNDERLYING TREATMENTS
Open this folder and view contents5. PRACTICAL CONSIDERATIONS IN STI CASE MANAGEMENT
Open this folder and view contents6. CHILDREN6, ADOLESCENTS AND SEXUALLY TRANSMITTED INFECTIONS
View the documentANNEX. LIST OF PARTICIPANTS
 

Uncomplicated anogenital infection

Recommended regimens

• ciprofloxacin, 500mg orally, as a single dose

OR

• azithromycin, 2g orally, as a single dose

OR

• ceftriaxone, 125mg by intramuscular injection, as a single dose

OR

• cefixime, 400mg orally, as a single dose

OR

• spectinomycin, 2g by intramuscular injection, as a single dose.

Note

• Ciprofloxacin is contraindicated in pregnancy, and is not recommended for use in children and adolescents.

• There is accumulating evidence that the cure rate of Azithromycin for gonococcal infections is best achieved by a 2-gram single dose regime. The 1-gram dose provides protracted sub-therapeutic levels which may precipitate the emergence of resistance.

There are variations in the anti-gonococcal activity of individual quinolones, and it is important to use only the most active.

Alternative regimens which may be useful in some countries, depending on the prevalence of resistant gonococci:

• kanamycin, 2g by intramuscular injection as a single dose

OR

• trimethoprim (80mg)/sulfamethoxazole (400mg), 10 tablets orally, as a single dose daily for 3 days.

Note

• Kanamycin and trimethoprim/sulfamethoxazole should only be used in areas where in vitro resistance rates are low and are monitored at regular intervals. In addition, second-line treatment with recommended drugs should be available.

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