(2000; 28 pages) [French]
8.1 Hypothesis generation and strengthening
A major aim of pharmacovigilance is the early detection of hypotheses or signals (see Glossary) with regard to possible adverse reactions. Early signals may be too uncertain, however, to justify firm conclusions and regulatory action, and may need further study (see § 8.5). A signal may be strengthened by combining the experiences reported in various countries. Therefore international collaboration is important.