WHO Model Prescribing Information: Drugs Used in Parasitic Diseases - Second Edition
(1995; 152 pages) [French] [Spanish] View the PDF document
Table of Contents
View the documentPreface
Open this folder and view contentsProtozoa
Close this folderHelminths
Close this folderCestode (tapeworm) infection
View the documentAlbendazole
View the documentMebendazole
View the documentNiclosamide
View the documentPraziquantel
Open this folder and view contentsIntestinal nematode infection
View the documentTissue nematode infections
Open this folder and view contentsLoiasis
Open this folder and view contentsLymphatic filariasis
Open this folder and view contentsOnchocerciasis
Open this folder and view contentsSchistosomiasis
Open this folder and view contentsIntestinal, liver and lung flukes
View the documentSelected WHO publications of related interest
View the documentBack cover
 

Niclosamide

Group: anthelminthic agent
Chewable tablet 500 mg

General information

An anthelminthic that blocks glucose uptake by intestinal tapeworms.

It is a safe drug because very little is absorbed from the gastrointestinal tract.

Clinical information

Uses

Treatment of infection due to Taenia saginata, T. solium, Hymenolepis nana and Diphyllobothrium latum.

It is not active against the larval form of T. solium (cysticerci).

Dosage and administration

The tablets should be chewed thoroughly before swallowing and washed down with a little water.

Adults: 2 g as a single dose.

Children:

< 10 kg: 0.5 g as a single dose
10-35 kg: 1 g as a single dose.

Chronically constipated patients should receive a purgative the previous evening.

H. nana infections should be treated for 7 consecutive days: for adults, 2 g on day 1 followed by 1 g daily for 6 days.

Contraindications

There are no known contraindications to the use of niclosamide.

Use in pregnancy

Niclosamide has not been shown to be mutagenic, teratogenic or embryotoxic. Because of the risk of cysticercosis T. solium intestinal infections should always be treated without delay.

Adverse effects

Mild gastrointestinal disturbances may occur.

Overdosage

A laxative or an enema may be of value. Emesis should not be induced in possible cases of T. solium infection because of the risk that retrograde passage of eggs may result in cysticercosis.

Storage

Tablets should be stored in well-closed containers, protected from light.

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