(1995; 152 pages) [French] [Spanish]
Group: anthelminthic agent
Chewable tablet 500 mg
An anthelminthic that blocks glucose uptake by intestinal tapeworms.
It is a safe drug because very little is absorbed from the gastrointestinal tract.
Treatment of infection due to Taenia saginata, T. solium, Hymenolepis nana and Diphyllobothrium latum.
It is not active against the larval form of T. solium (cysticerci).
Dosage and administration
The tablets should be chewed thoroughly before swallowing and washed down with a little water.
Adults: 2 g as a single dose.
< 10 kg: 0.5 g as a single dose
10-35 kg: 1 g as a single dose.
Chronically constipated patients should receive a purgative the previous evening.
H. nana infections should be treated for 7 consecutive days: for adults, 2 g on day 1 followed by 1 g daily for 6 days.
There are no known contraindications to the use of niclosamide.
Use in pregnancy
Niclosamide has not been shown to be mutagenic, teratogenic or embryotoxic. Because of the risk of cysticercosis T. solium intestinal infections should always be treated without delay.
Mild gastrointestinal disturbances may occur.
A laxative or an enema may be of value. Emesis should not be induced in possible cases of T. solium infection because of the risk that retrograde passage of eggs may result in cysticercosis.
Tablets should be stored in well-closed containers, protected from light.